CDC Advisors Recommend Novavax Covid Vaccine For Adults

Topline

A Centers for Disease Control and Prevention advisory committee recommended approving Novavax’s Covid-19 vaccine for adults on Tuesday, one week after the protein-based vaccine received emergency authorization from the Food and Drug Administration, as the United States contends with a fast-moving new coronavirus strain.

Key Facts

Key Background

The Novavax vaccine repeatedly performed well in early trials, but has faced manufacturing issues over its two-year development. In a trial conducted in the U.S. and Mexico, the vaccine proved to be 90.4% effective in preventing mild, moderate or severe infections, with no cases of moderate or severe Covid-19 reported among the 17,200 trial participants who received it. For adults 65 and older, the vaccine was 78.6% effective. Another study in February found an 82.7% rate over a six-month period when used as a booster, although testing was conducted before omicron became the dominant variant. Last month, however, Novavax shares fell roughly 20% after the FDA raised concerns over a potential risk of heart inflammation, and nearly a year after it failed to meet the FDA’s quality standards in its production process. The Maryland-based pharmaceutical company hopes the vaccine, which uses a small “spike protein” to trigger an immune system response—a similar structure to long-used vaccines for the flu, hepatitis B and shingles—could convince Americans skeptical of mRNA-based vaccines like Pfizer/BioNTech and Moderna to get vaccinated. Roughly 10.2% of U.S. adults have not received a single vaccine dose, according to data from the CDC.

Big Number

3.2 million. That’s how many Novavax vaccines the Biden Administration secured last week. In a statement, the administration said it would release the doses once the pharmaceutical company completes testing, which the federal government expects to happen in the coming weeks.

Tangent

Novavax has already been authorized for use in more than 40 countries, including Australia, Canada and the United Kingdom, and it received authorization from the European Union and the World Health Organization.

Contra

Some 77% of unvaccinated adults said they would not get a protein-based Covid-19 shot if one were authorized in the U.S., according to a Morning Consult poll released last month, but unvaccinated adults are more likely to trust the safety of protein-based vaccines (28%) than mRNA shots (17%).

What To Watch For

Novavax could enter the U.S. vaccine arsenal as the country contends with a new dominant coronavirus strain. Earlier this month, the highly transmissible BA.5 omicron subvariant became the dominant strain. The subvariant accounted for nearly 80% of Covid-19 infections nationwide last week, up from 29% in the week ending June 18, according to the CDC.

Further Reading

FDA Authorizes Novavax’s Covid-19 Vaccine For Adults (Forbes)

U.S. Secures 3.2 Million Novavax Covid Vaccines — Offering Alternative To MRNA Shots As New Variant Spreads (Forbes)

New Novavax Covid-19 Vaccine: Here Are 3 Things Different About It (Forbes)

Novavax Stock Halted Pending FDA Panel Meeting—Here’s What To Know About The Company’s Covid Vaccine (Forbes)

Full coverage and live updates on the Coronavirus