“Despite decades of research, we still lack therapeutic measures and interventions to prevent AMD or slow down progression, underscoring the need for better understanding and novel prevention or therapeutic strategies.
“Previous studies investigated the relation of AMD and different systemic medications, which interfere with pathways that also play a role in AMD pathogenesis and hence may affect it.
“These include lipid-lowering drugs (LLD) for the lipid metabolism and lipid accumulation, non-steroidal anti-inflammatory drugs (NSAID) and antidiabetic drugs (particularly metformin), which may reduce inflammation and oxidative stress, and levodopa (L-Dopa), which was reported to upregulate the retinal pigment epithelium (RPE) metabolism.
“Results of studies to date, however, have been inconsistent, based on small sample size or using self-reported AMD as outcome.
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