Anne Adams was an accomplished scientist. Then, as dementia claimed her brilliant mind, she became an accomplished and resolute artist — painting increasingly beautiful and elaborate works.
During the early stages of her illness, she created complex visual interpretations of classical music, such as George Gershwin’s Rhapsody in Blue and Maurice Ravel’s Boléro. Then she shifted to painting even more abstract concepts, such as numbers.
A recent UC San Francisco-led study of brain scans of Adams and other patients with the deadly “frontotemporal” variety of dementia has revealed the underlying mechanism behind this mysterious shift in creative expression.
As the brain region responsible for language is dying, it activates the visual processing area that drives creativity, according to Dr. Bruce Miller, the senior author of the recent study, a collaboration of 27 scientists published in the journal JAMA Neurology.
“This is a way that the brain copes with an insult,” said Miller, director of the UCSF Memory and Aging Center. “It mobilizes whatever circuits are still available and untouched.”
Similar yet different changes may help explain the mood and behavioral shifts sometimes seen in patients who have had other brain injuries or illnesses, such as stroke or Alzheimer’s disease, he said.
The UCSF research also offers insights into the workings of the healthy brain, engaged in a constant dance — some circuits turning on and others turning off.
On Friday night, Adams’ story — which, uncannily, parallels a similar burst of creativity and mental decline in the composer Ravel a century earlier — will be told on stage at the San Francisco Conservatory of Music in a one-night performance of the play UnRavelled. The performance will be followed by a 30-minute panel discussion on creativity and brain science by UCSF’s Miller and other experts.
“It is a very beautiful, sad story that captures the birth of something extraordinary,” said Miller.
Frontotemporal dementia (FTD), which affects about 60,000 Americans, is different from Alzheimer’s disease. It typically affects people younger — in their 50s and 60s — such as actor Bruce Willis. It doesn’t affect memory; rather, it changes behavior and language. It is incurable, and there are no approved therapies to slow or alter its course.
Scientists previously thought that neurodegenerative diseases hit the brain everywhere, at once. Now they know that they start in a very small and specific region of the brain, targeting certain cells. But over time, the damage spreads and is lethal.
Misfolded proteins build up in the frontal and temporal lobes. This part of the brain does a lot of things — but its most important job is language and social behavior.
A small subset of patients with a specific variant of FTD show a burst of visual creativity as they decline — painting or making montages, pottery, sculpture, jewelry, quilts, even welding colorful insect-like creatures.
Patients who were artists become more visually obsessed. But even people with no previous interest in art become engaged in their new hobby for many hours a day.
When healthy, UCSF patient Victor Wightman had no interest in art; he enjoyed running, swimming and basketball. But at age 48, a year before his FTD diagnosis, he began painting images of animals and cartoon characters in vivid, almost electric, colors.
Another patient, Jancy Chang, was a talented Santa Cruz artist and teacher. After retirement at age 52 due to declining language skills, her paintings became much bolder, wilder and more original.
The link between FTD and new artistic talent was first described by Miller in 2007 in the journal Brain. The new UCSF study, led by behavioral neurologist Dr. Adit Friedberg, sought to understand why.
The team analyzed the records of 689 FTD patients and identified 17, or 2.5%, who had experienced a burst in visual creativity at the start of their dementia.
The scans revealed that the region of the frontal cortex, responsible for language, had shrunk in visually creative patients, while areas in the back of the brain on the right side, devoted to visual and spatial processing, were more active.
In healthy people, these visual regions may be inhibited by the dominant frontal cortex, said Miller. But when damaged, creativity is released.
Periodic brain scans at UCSF offered a remarkable glimpse of changes in Anne Adams, from her diagnosis in 1997 until her death in 2007.
Trained in physics and chemistry, she earned a PhD in cell biology while raising four children. She taught and did research at the University of British Columbia, then left her career to take care of an injured son. To pass the time, she turned to art. Her initial works were simple drawings and architectural watercolors.
“She was very bright, and she was also artistic,” said her widower Robert Adams, 83, a professor emeritus of math at the University of British Columbia.
Increasingly drawn to repetition and abstraction, her work turned more vibrant. In a rendering of the mathematical ratio pi, she mapped a vivid matrix of its first 1,471 digits.
Her most ambitious piece, which took three months, deconstructed Ravel’s famous song Boléro. The insistent, rhythmic plod of the music — all 340 bars — was transformed into symbols and colors. The A note was painted silver; A-flat, copper; B, leaf green; B-flat, metallic green, and so on.
Just like Boléro‘s melody, her symbols repeated and repeated. With each crescendo, the rectangles grew taller.
Scientists now suspect that in the late 1920s, when Ravel composed Boléro, he also suffered from FTD. A man of order and perfection, his behavior turned erratic. Within several years, he lost the ability to translate music from his mind into notes.
Soon Anne began to struggle to find words and add numbers. Her paintings grew increasingly symmetrical. Her final works, achieved when she was nearly mute, moved towards photographic realism.
Tragically, the illness slowly claimed both Anne’s words and skills. But her drive to paint persisted.
“She got to the stage where she’d come down, sit down at her desk, with the paints in front of her,” said Robert Adams. “And she’d just look at them.”
UnRavelled:
When: Friday, July 21 2023, 7:30 p.m.
Where: Caroline H. Hume Concert Hall, San Francisco Conservatory of Music
50 Oak Street, San Francisco, CA
To reserve a seat: https://sfcm.edu/experience/performances/unravelled
Stay connected with us on social media platform for instant update click here to join our Twitter, & Facebook
We are now on Telegram. Click here to join our channel (@TechiUpdate) and stay updated with the latest Technology headlines.
For all the latest Education News Click Here
