In reply, the Titans reached the target in 19.2 overs.
Shubman Gill was the top scorer for the Titans, scoring a 36-ball 63.
Earlier, Gaikwad smashed nine sixes even though wickets fell at regular interval at the other end.
For the Titans, spinner Rashid Khan (2/26) and pacers Mohammed Shami (2/29) and Alzarri Joseph (2/33) picked two wickets each.
Brief Scores: 178 for 7 in 20 overs (Ruturaj Gaikwad 92; Moeen Ali 23; Rashid Khan 2/26, Mohammed Shami 2/29, Alzarri Joseph 2/33)
Gujarat Titans 182 for 5 in 19.2 overs (Shubman Gill 63; Rajvardhan Hangargekar 3/36).
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