Having ensured a series victory with a five-wicket win over the tourists at Trent Bridge last week, England go in search of a 3-0 triumph when they head to Headingley for the third and final Test.
They will be without Anderson – who claimed 11 wickets across the first two Tests – for that contest after the paceman suffered an ankle injury.
But Stokes, who was originally a doubt himself after feeling unwell, hopes the addition of Overton to the XI will provide a boost for Brendon McCullum’s men.
“Unfortunately Jimmy has not pulled up as well as we would have liked,” the skipper told Sky Sports. “So Jamie Overton is going to make his debut this week.
“It’s unfortunate for Jimmy but we’ve obviously got a massive Test match against India next week to look to as well. He didn’t pull up as well, so it’s great Jamie gets the opportunity to represent England.”
Asked about Overton’s potential, Stokes added: “He’s been very impressive.
“The way that he’s bowled, we always want a point of difference in our side, and Jamie’s been bowling with some serious pace and been changing games as well.
“So to have someone come in, in obviously a different role to what Jimmy normally plays, and in the back pocket having someone who can bowl 90 miles an hour and bowl aggressively, is exciting to have in the team.”
Overton has taken 21 wickets for County Championship Division One leaders Surrey at an average of 21.61 this season.
His twin brother Craig was also called up to the England squad for the final Test but has narrowly missed out on selection.
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