Ryanair staff will strike from 12 to 15 July, 18 to 21 July and 25 to 28 July across Spanish airports.
The airline has bases at Barcelona, Palma de Mallorca and Malaga which are likely to be affected by action.
The USO union has asked the Spanish Government to mediate in the situation and called on all Spanish Ryanair workers to support the strike.
Strikes in June caused more than 1,000 delays in Spain and some action coincided with easyJet strikes.
READ MORE: Airport chaos: All countries reporting major delays and queues
Ryanair had 10 cancellations in Spain on Saturday and 123 delays affecting routes from London and Glasgow.
easyJet has also been impacted by strike action with some London flights affected by cancellations.
easyJet staff are due to take part in strikes in Spain on July 15, 16, 17, 29, 30 and 31.
The coming strikes could upset British holidaymakers’ plans as they are set to coincide with UK school holidays.
DON’T MISS
The Government has asked airlines to cut schedules ahead of the peak summer period to avoid last minute cancellations.
Passengers whose flight is cancelled are entitled to another flight on their intended day of travel if one is available.
They could be entitled to cash compensation if their flight is cancelled with less than two weeks notice.
Cash payouts will depend on the length of the flight and whether the airline is responsible.
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