A pooled analysis of 15 different clinical studies published in the American Journal of Clinical Nutrition in 2015, looked at over 11,000 cases, to determine association of levels of vitamins and cancer risk.
In this very large sample size, levels of retinol were positively associated with prostate cancer risk.
Furthermore, an observational analysis of over 29,000 samples from the alpha-tocopherol, beta-carotene cancer prevention study conducted by National Cancer Institute (NCI), National Institute of Health (NIH), USA, reported that at the three year follow-up, men with higher serum retinol (Vitamin A) concentration had an elevated risk of prostate cancer.
Finally, a more recent analysis of the same NCI driven alpha-tocopherol, beta-carotene cancer prevention study of over 29,000 participants between 1985-1993 with a follow-up to 2012, confirmed the earlier findings of the association of higher serum retinol concentration with increased risk of prostate cancer.
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