Two bruising away days against Liverpool and West Ham saw Mikel Arteta’s men surrender a pair of 2-0 leads to bring Manchester City within four points along with their game in hand.
A return to winning ways this evening is almost a necessity, given the rivals clash in their titanic title showdown in Manchester next Wednesday.
Southampton, meanwhile, are rooted to the foot of the Premier League table, four points from safety, with just seven matches left of the campaign.
What time does the game kick-off?
Arsenal vs Southampton will kick-off tonight (Friday, April 21) at 8pm BST.
How to watch on TV and live stream
The game will be shown live on Sky Sports Main Event and Sky Sports Premier League, with coverage getting underway from 7pm on both channels.
Sky customers can also watch on live stream on the Sky Sports website and with the Sky Go app.
Fans who do not have Sky Sports can purchase a NOW TV day pass for £11.98.
How to listen on radio
Live radio coverage will take place on talkSPORT from 7pm.
Team news
Arsenal will be desperate for the return of Oleksandr Zinchenko, who sat out the draw with West Ham last weekend with a groin complaint.
The influential Ukrainian has since returned to training but Arteta is unsure if Zinchenko will be passed fit to play any part later tonight.
William Saliba is definitely ruled out, however, with Arteta suggesting the Frenchman is still someway off a return to fitness.
Mohamed Elneny and Takehiro Tomiyasu remain in the treatment room and will not play again this season.
The Saints will be without the injured duo of Che Adams and Mohammed Salisu, whilst Ainsley Mailtand-Niles is unavailable to face his parent club.
MORE : Mikel Arteta makes decision over Arsenal’s penalty taker following Bukayo Saka miss
MORE : Mikel Arteta sends warning to Arsenal star Emile Smith Rowe after West Ham snub
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